Preclinical evaluation of a low-frequency transcranial MRI-guided focused ultrasound system in a primate model
نویسندگان
چکیده
منابع مشابه
Preclinical evaluation of a low-frequency transcranial MRI-guided focused ultrasound system in a primate model.
This study investigated thermal ablation and skull-induced heating with a 230 kHz transcranial MRI-guided focused ultrasound (TcMRgFUS) system in nonhuman primates. We evaluated real-time acoustic feedback and aimed to understand whether cavitation contributed to the heating and the lesion formation. In four macaques, we sonicated thalamic targets at acoustic powers of 34-560 W (896-7590 J). Ti...
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Focused ultrasound (FUS) disruption of the blood-brain barrier (BBB) is an increasingly investigated technique for circumventing the BBB(1-5). The BBB is a significant obstacle to pharmaceutical treatments of brain disorders as it limits the passage of molecules from the vasculature into the brain tissue to molecules less than approximately 500 Da in size(6). FUS induced BBB disruption (BBBD) i...
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Methods The animal was deeply anesthetized using ketamine and dexdormitor. First we targeted the LGN using MR temperature imaging, and then we relocated the MRI table just outside the MRI. Visually-evoked potentials driven by a strobe light were recorded transcranially using electrodes placed over the visual cortex. Recordings were obtained before, during, and after sonications at different tar...
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Background: Recently, ultrasonic neuromodulation research has been an important and interesting issue. Ultrasonic neuromodulation is possible by the use of low-intensity transcranial focused ultrasound (tFUS) to stimulate or inhibit the neural structures. The primary capability of this method is the improvement in the treatment progress of certain neurological and psychiatric disorders noninvas...
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MRI-guided focused ultrasound is a new technology that enables intracranial ablation. Since lesioning ameliorates some of the symptoms of PD, this technology is being explored as a possible treatment for medication resistant symptoms in PD patients. The purpose of this paper is to review the clinical use and treatment outcomes of PD patients treated to date with this technology.
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ژورنال
عنوان ژورنال: Physics in Medicine and Biology
سال: 2016
ISSN: 0031-9155,1361-6560
DOI: 10.1088/0031-9155/61/21/7664